The Longevity Molecule

What is NAD+

Nicotinamide Adenine Dinucleotide, NAD+ is the active form of a coenzyme found in every cell in your body. 


NAD+ = Energy

NAD+ helps to turn carbohydrates, fats, and proteins in the body into useable energy via the Citric Acid Cycle (Krebs Cycle). This important chemical reaction results in the production of ATP.  ATP is the energy currency of life, powering nearly every body activity such as muscle contraction, protein manufacturing, and cellular communication. Without NAD+ your cells would not be able to create energy from the fats, protein and carbohydrates you eat.

Because NAD+ is so critical for energy production many elite athletes use NAD+ before events or to aid in recovery from training. 


Repairs DNA

NAD+ does much more than just create energy for our cells, it also is necessary for turning on a family of genes called Sirtuins that are essential for DNA repair.  Our DNA is constantly under being damaged by the simple process of being alive. The good news is our body has a build in repair process.  One of the main ways our body accomplishes this feat is by activating sirtuins.  However when NAD+ levels are low it sends a signal that energy is needed elsewhere in the body and the Sirtuin genes are turned off. 

As you age NAD+ stores decline which results in decreased Sirtuin activation, and as a result decreased ability of your body to repair DNA.  Scientists believe that by the time we reach our 40’s, the supply of NAD+ is no longer able to meet the demand for important biological processes. Additionally, sickness and disease, as well as environmental and self-induced stressors can rapidly deplete our body of this vital nutrient.  


Additionally, low levels of NAD+ may contribute to fatigue, depression, and anxiety. It hinders our body’s ability to overcome the grip of drug and alcohol addiction. Additionally, low levels of NAD+ may contribute to worsening disease states in vital organs such as the heart, liver, and brain. NAD+ depletion weakens our immune system, the ability to fight infection and even slow the progression of cancer. 


NAD+ Has been used for:


  • Slowing the aging process
  • Athletic performance
  • Anxiety, depression and PTSD
  • Drug and alcohol addiction
  • Cravings for drugs and alcohol after detox (PAWS)
  • Early Parkinson’s disease
  • Early Alzheimer’s disease
  • Early dementia
  • Multiple sclerosis
  • Other neurodegenerative disorders
  • “Chemo Brain”
  • Low energy levels
  • Chronic Fatigue Syndrome
  • Sleep disturbances
  • Chronic pain syndromes
  • Migraine headaches
  • Autoimmune diseases
  • Autoinflammatory diseases
  • Chronic Traumatic Encephalopathy (CTE)

IV NAD+ Therapy

What is the Course of Treatment for NAD+?

For general health and longevity most people choose to have a single NAD+ infusion every 1-3 months.


For many of the conditions listed above a treatment protocol consists of 3-5 days of consecutive IV infusions for best results.


For drug and/or alcohol detoxification protocols range from 8-14 days.


Call us to speak to Dr. Smiley about what treatment is be best for you. 



What Can I Expect During the NAD+ Treatment?

 A brief assessment will be conducted on the day of treatment. For intravenous NAD+, a small IV will be inserted. The infusion will run for approximately 3-4 hours.


The side effects of treatment are minimal and are related to the rate at which the NAD+ is administered. At a faster rate, patients may experience slight upper torso pressure, abdominal cramping and lower leg soreness. Flushing, mild nausea and a slight headache may also occur. These side effects usually disappear within 15-30 seconds of slowing the rate of infusion. Patients are able to pass the time in our relaxing clinic environment by watching TV, reading, and listening to music. You will also have access to high-speed internet and can bring your laptop for personal use.


All of our NAD+ infusions are followed by a vitamin infusion to increase absorption and uptake of the NAD+ into your cells. 

NAD+/Price List

Articles on NAD+

NAD+ and Sirtuins in Aging and Diseas

NAD+ in aging, metabolism and neurodegeneration

NAD+ and Sirtuins in Aging and Diseas

NAD, Sirtuins, National Center for biotechnology

NAD+ in aging, metabolism and neurodegeneration

NAD+ in aging, metabolism and neurodegeneration

"I got a brain 'reboot' and it changed my world"

Science, NAD,

"I got a brain 'reboot' and it changed my world"

NAD+ as the Link Between Oxidative Stress, Inflammation, Caloric Restriction, Exercise, DNA Repair

"I got a brain 'reboot' and it changed my world"

image26

NAD+ as the Link Between Oxidative Stress, Inflammation, Caloric Restriction, Exercise, DNA Repair

NAD+ as the Link Between Oxidative Stress, Inflammation, Caloric Restriction, Exercise, DNA Repair

NAD+ as the Link Between Oxidative Stress, Inflammation, Caloric Restriction, Exercise, DNA Repair

rejuvenation research, NAD, aging, longevity,

Brain Restoration: ‘Too Good To Be True’ for Addiction and Disease?

NAD+ as the Link Between Oxidative Stress, Inflammation, Caloric Restriction, Exercise, DNA Repair

NAD+ as the Link Between Oxidative Stress, Inflammation, Caloric Restriction, Exercise, DNA Repair

The Fix, Brain Restore, Dr. Mestayer, springfield wellness center